Arduino Nano 33 IoT vs ESP32 - What is the difference?

Last Updated May 25, 2025

The ESP32 offers higher processing power, built-in Wi-Fi and Bluetooth, and more GPIO pins compared to the Arduino Nano 33 IoT, which is designed specifically for IoT applications with integrated secure connectivity and an ARM Cortex-M0+ processor. Discover which board suits your project needs by reading the full comparison in this article.

Comparison Table

Feature ESP32 Arduino Nano 33 IoT
Microcontroller Dual-core Tensilica LX6, up to 240 MHz Arm Cortex-M0+ 32-bit SAMD21, 48 MHz
Wireless Connectivity Wi-Fi 802.11 b/g/n, Bluetooth 4.2/BLE Wi-Fi 802.11 b/g/n, BLE 5.0
Flash Memory 4 MB to 16 MB (varies by module) 256 KB
SRAM 520 KB 32 KB
Operating Voltage 3.3 V 3.3 V
Digital I/O Pins 34 GPIO pins 14 GPIO pins
Analog Input Pins 18 ADC channels 8 ADC channels (12-bit)
PWM Channels 16 Channels ~10 Channels
USB Interface Micro USB (varies by board) Micro USB
Power Consumption ~80 mA active, deep sleep ~10 uA ~80 mA active, deep sleep ~500 uA
Security Features Hardware encryption (AES, SHA, RSA, ECC) Secure Element (ECC508) for crypto authentication
Price Range $4 - $10 $18 - $25
Ideal Use Cases IoT devices, wireless communication, high performance Secure IoT applications, lightweight embedded systems

Introduction to ESP32 and Arduino Nano 33 IoT

ESP32 features a dual-core processor with integrated Wi-Fi and Bluetooth, offering robust performance for IoT applications. Arduino Nano 33 IoT combines a SAMD21 Cortex-M0+ processor with secure Wi-Fi connectivity, optimized for lightweight tasks and rapid prototyping. Your choice depends on the complexity and connectivity needs of your IoT project.

Core Features and Specifications

The ESP32 features a dual-core 32-bit LX6 microprocessor running up to 240 MHz, integrated Wi-Fi 802.11 b/g/n, and Bluetooth 4.2 connectivity, making it ideal for high-performance IoT projects. In contrast, the Arduino Nano 33 IoT utilizes a single-core ARM Cortex-M0+ processor at 48 MHz and offers Wi-Fi and Bluetooth LE through a u-blox NINA-W102 module, prioritizing low power consumption and ease of use. Your choice depends on whether you need raw processing power and dual-core multitasking (ESP32) or simplified IoT integration with Arduino's robust ecosystem (Nano 33 IoT).

Processing Power and Memory

The ESP32 features a dual-core Xtensa LX6 processor running at up to 240 MHz, providing significantly higher processing power compared to the Arduino Nano 33 IoT's 32-bit ARM Cortex-M0+ processor at 48 MHz. ESP32 offers up to 520 KB of SRAM, while Arduino Nano 33 IoT includes 32 KB of SRAM and 256 KB of flash memory. This substantial difference in CPU speed and memory capacity makes the ESP32 more suitable for complex IoT applications requiring higher computational demands and larger data handling.

Connectivity Options: Wi-Fi and Bluetooth

The ESP32 offers robust connectivity with dual-mode Bluetooth (Classic and BLE) and integrated Wi-Fi support, making it ideal for IoT applications requiring versatile wireless communication. The Arduino Nano 33 IoT features Wi-Fi through the u-blox NINA-W102 module and Bluetooth Low Energy (BLE), providing reliable, low-power wireless options suited for compact projects. Your choice depends on whether dual-mode Bluetooth on the ESP32 or the streamlined BLE and Wi-Fi combo on the Nano 33 IoT better fits your project's connectivity needs.

Power Consumption and Efficiency

The ESP32 offers a wide range of low-power modes, including deep sleep, with power consumption as low as 10 uA, making it highly efficient for battery-powered IoT applications. The Arduino Nano 33 IoT consumes slightly more power in active mode, around 20 mA, but leverages the SAMD21 microcontroller's ultra-low-power features and optimized power management for energy efficiency. Both devices support efficient power handling, but the ESP32's advanced sleep modes and integrated Wi-Fi/Bluetooth radio power management provide superior overall power consumption control in complex wireless projects.

Development Ecosystem and Programming

ESP32 offers a robust development ecosystem with support for ESP-IDF, Arduino IDE, and MicroPython, providing extensive libraries and resources for IoT projects. Arduino Nano 33 IoT seamlessly integrates with the Arduino ecosystem, featuring easy-to-use IDE support and built-in secure communication libraries tailored for IoT security. Your choice depends on whether you prioritize ESP32's versatile programming options or Nano 33 IoT's simplified Arduino experience with enhanced IoT features.

Hardware Peripherals and Expansion

The ESP32 features dual-core processors, integrated Wi-Fi and Bluetooth modules, and a rich set of hardware peripherals including multiple SPI, I2C, UART interfaces, and ADC/DAC channels, making it highly versatile for complex IoT projects. In contrast, the Arduino Nano 33 IoT is equipped with a single-core ARM Cortex-M0+ microcontroller, an embedded u-blox NINA-W102 module for Wi-Fi and Bluetooth, and offers fewer GPIO pins but includes built-in sensors like a 6-axis IMU, optimizing it for compact IoT applications. Expansion capabilities differ as the ESP32 supports extensive GPIO multiplexing and external memory integration, while the Arduino Nano 33 IoT focuses on ease of use with Arduino shields and a compact form factor suitable for rapid prototyping.

Security Features and Updates

The ESP32 offers built-in hardware security features such as secure boot, flash encryption, and integrated cryptographic hardware accelerators, ensuring robust protection for IoT devices. The Arduino Nano 33 IoT enhances security with its ECC508 crypto chip, enabling secure authentication and encrypted communication for IoT applications. You can rely on regular firmware updates from both platforms to address vulnerabilities and improve security protocols over time.

Price Comparison and Value

The ESP32 generally offers a lower price point compared to the Arduino Nano 33 IoT, making it a cost-effective choice for budget-conscious projects. Despite the higher cost, the Arduino Nano 33 IoT delivers integrated Wi-Fi, Bluetooth, and advanced security features, providing excellent value for IoT applications. Your decision should weigh the balance between cost savings and the specific connectivity or security requirements of your project.

Application Scenarios and Use Cases

ESP32 excels in applications requiring robust Wi-Fi and Bluetooth connectivity, making it ideal for IoT projects like smart home devices, wearable technology, and real-time data monitoring. Arduino Nano 33 IoT offers a compact, user-friendly solution with built-in secure Wi-Fi and cryptographic features, perfect for sensing, remote control, and lightweight IoT applications with security needs. Your choice depends on whether you prioritize higher processing power and wireless flexibility (ESP32) or seamless integration with Arduino ecosystems and enhanced IoT security (Nano 33 IoT).

esp32 vs arduino nano 33 iot Infographic

Arduino Nano 33 IoT vs ESP32 - What is the difference?


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The information provided in this document is for general informational purposes only and is not guaranteed to be complete. While we strive to ensure the accuracy of the content, we cannot guarantee that the details mentioned are up-to-date or applicable to all scenarios. Topics about esp32 vs arduino nano 33 iot are subject to change from time to time.

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